Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer
نویسندگان
چکیده
منابع مشابه
Role of Cyclooxygenese-2 (COX-2) Expression in Breast Cancer Differentiation and Its Relationship with Hormone Receptors Status
Background and Objectives: Cyclooxygenese-2 (COX-2) expression in breast cancer and its correlation with tumor prognosis is unclear. We investigated the incidence of COX-2 expression in patients and assessed interactions between COX-2 and clinical features of cancer and expression of HER2/neu, estrogen receptor (ER), and progesterone receptor (PR). Methods: COX-2 expression was investigated by...
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Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, COX-2 expression may be a universal phenomenon. In general, COX-2 is up-regulated throughout the tumorigenic process, from early hyperplasia to metastatic disease. COX-2 has been reported ...
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Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...
متن کاملrole of cyclooxygenese-2 (cox-2) expression in breast cancer differentiation and its relationship with hormone receptors status
background and objectives: cyclooxygenese-2 (cox-2) expression in breast cancer and its correlation with tumor prognosis is unclear. we investigated the incidence of cox-2 expression in patients and assessed interactions between cox-2 and clinical features of cancer and expression of her2/neu, estrogen receptor (er), and progesterone receptor (pr). methods: cox-2 expression was investigated by...
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Background and objective: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer. Mater...
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ژورنال
عنوان ژورنال: Indian Journal of Surgical Oncology
سال: 2014
ISSN: 0975-7651,0976-6952
DOI: 10.1007/s13193-014-0290-y